Phospholipids have been the subjects of considerable interest due to their importance in biological system. Conventional glycerol-based phospholipids such as phosphatidyl cholines self-assemble in water as spherical three dimensional closed structures known as liposomes. The potential applications of liposomes are numerous and include their uses as drug delivery materials, gene transfection agents and biological membrane model. Chemical modification at different parts of a phospholipid's structure can affect its activity in biological processes, especially in cell membrane. For the past several decades, a number of modifications of hydrophobic tail and hydrophilic head groups and structural variants of its glycerol units and carbohydrate-based phospholipids have been reported. Recently, the synthesis and physicochemical study of uridine-based phospholipids were reported. In this paper, we report the synthesis of cytidine-, guanosine-based phosphocholines having saturated acyl chain at 2'-, 3'- position of nucleosides as shown in Figure 1.
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