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首页> 外文期刊>Genetics: A Periodical Record of Investigations Bearing on Heredity and Variation >What lies beyond uranus? Preconceptions, ignorance, serendipity and suppressors in the search for biology's secrets.
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What lies beyond uranus? Preconceptions, ignorance, serendipity and suppressors in the search for biology's secrets.

机译:天王星之外还有什么?寻找生物学秘密的先入为主,无知,偶然和压制者。

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摘要

DISULFIDE bonds in proteins-how these bonds are formed, how they are cleaved, and how they participate in protein folding-have become my passion over the past 25 years. During this period, the discoveries in my lab in this very biochemical realm have come largely from genetic approaches. Many factors have influenced the pace of our progress, including at times ignorance of certain biochemical dogma and at other times unreflective adherence to such dogma. We have been impelled by the conviction that well-thought-out genetic approaches can yield insights into how processes of protein chemistry occur in a living cell. Yet, despite our carefully constructed "rational" approaches, serendipity, a workhorse of science, has consistently led us in unexpected directions.
机译:蛋白质中的二硫键-这些键的形成方式,它们的裂解方式以及它们如何参与蛋白质折叠-在过去25年中成为我的激情所在。在此期间,我实验室在这个生化领域的发现主要来自遗传方法。许多因素影响了我们的进步步伐,包括有时对某些生化教条的无知和在其他时候对这种教条的不依从。深信不疑的是,深思熟虑的遗传方法可以使人们深入了解活体细胞中蛋白质化学过程的发生方式。然而,尽管我们精心构造了“理性”的方法,但偶然性却是科学的主力军,始终引领着我们走向意想不到的方向。

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