Ab initio Calculations for Exploring Metal lon-(Gly-Gly-His)Complexes

摘要

The specific interactions in metal ion-peptide systems have been studied in many research groups.It is known that the coordinated metal ions play a significant role in the biological action of peptide.Several experimental techniques have been applied to present of specific interactions in metal ion-peptide complexes.Conformations of metal ion binding to peptides may have a critical impact on the peptide folding processes and peptide biological functions.Among metal ions,Cu~(2+)and Ni~(2+)have been widely studied and seem to have most interesting chemistry.Yang et al.reported that the specific interactions of peptides and metals could be applied for the fabrication of solid-state metal-ion biosensors.