Synthesis of 2,3,4-Trisubstituted 2,5-Dihydrofuran Derivatives

摘要

Recently,synthesis of methylenetetrahydrofurans has received much attention due to their versatile usefulness in organic synthesis.The compounds were prepared most frequently either by the Zn(II)/amine-catalyzed coupling reaction of alkylidenemalonates with propargyl alcohol or Michael addition of propargyl alcohol to alkylidenemalonates followed by a palladium-mediated exo-dig cyclization.Methylenetetrahydrofurans can be used for the synthesis of polysubstituted tetrahydrofurans or furans.However,chemical transformations of these valuable compounds were not reported much.