Synthesis of N-Benzyl 3,5-Disubstituted Piperidines via Double Michael Addition Strategy

摘要

Recently,Basavaiah and co-workers have reported the facile synthesis of functionalized 1,4-pentadienes from Baylis-Hillman type reaction from cinnamyl bromide derivatives(vide infra,Scheme l).However,the usefulness of the 1,4-pentadienes has not been studied extensively.We thought that we could prepare 3,5-disubstituted piperidine skeleton from these compounds via double Michael addition reaction strategy.