An Antibacterial 9,11-Secosterol from a Marine Sponge Ircima sp.

摘要

Marine sponges are a rich source of structurally diverse natural products and about 35% of marine natural products have been found from this chemically rich phylum of marine organisms.1 Many of the sponge metabolites have been reported as potent cytotoxins against cancer cell lines and several of them were used as a lead of FDA approved drugs such as Cytosar-U~R, and Halaven~R. A number of antibacterial compounds have also been reported from the marine sponge-derived metabolites including discorhabdin Z, agelasine D, 7,20-diisocyanoadociane, motualevic acid F. In this regard, we have been investigating the anti-bacterial compounds from extracts of Korean marine sponges. An extract of a marine sponge in the genus of Ircinia showed antibacterial activities and its bioactive constituents have been investigated.