Stereoselective Crossed-Aldol Condensation of Hetarylmethyl Ketones with Aromatic Aldehydes in Water : Synthesis of (2E)-3-Aryl-l-hetarylprop-2-en-l-ones

摘要

Aldol condensation of 2-acetylthiophene,2-acetylpyrrole and 2-acetylpyridine with different aromatic aldehydes were carried out in water in heterogeneous phases in the presence of cetyltrimethylammonium bromide as cationic surfactant at room temperature.All the reactions occur in a short time with excellent yields of steroselective hetarylpropanones in water as environmental friendly solvent.