Characterization of attenuated coxsackievirus B3 strains and prospects of their application as live-attenuated vaccines.

Kim DS; Nam JH

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Characterization of attenuated coxsackievirus B3 strains and prospects of their application as live-attenuated vaccines.

机译：减毒柯萨奇病毒B3株的表征及其作为减毒活疫苗的应用前景。

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Coxsackievirus strain CVB3 is widespread in the human population and causes myocarditis or pancreatitis. However, despite its clinical impact, there is no commercially available and clinically applicable prophylactic vaccine. This study examines the characteristics of attenuated CVB3 strains developed so far and their application as live-attenuated CVB3 vaccines, and discusses problems to be overcome in the development of live-attenuated vaccines.

机译：柯萨奇病毒株CVB3在人群中广泛分布，并引起心肌炎或胰腺炎。然而，尽管其具有临床影响，但尚无商购可得且临床上可应用的预防性疫苗。这项研究检查了迄今为止开发的减毒CVB3菌株的特性及其在减毒活CVB3疫苗中的应用，并讨论了在减毒活疫苗的开发中需要克服的问题。

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《Expert opinion on biological therapy》 |2010年第2期|共12页
作者
Kim DS; Nam JH;
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正文语种 eng
中图分类治疗学;
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1. Characterization of attenuated coxsackievirus B3 strains and prospects of their application as live-attenuated vaccines. [J] . Kim DS, Nam JH Expert opinion on biological therapy . 2010,第2期

机译：减毒柯萨奇病毒B3株的表征及其作为减毒活疫苗的应用前景。
2. Role of RNA structure motifs in ires-dependent translation initiation of the coxsackievirus B3: New insights for developing live-attenuated strains for vaccines and gene therapy [J] . Souii A., Ben MHadheb-Gharbi M., Gharbi J. Molecular biotechnology . 2013,第2期

机译：RNA结构基序在柯萨奇B3病毒依赖翻译的翻译中的作用：开发用于疫苗和基因治疗的减毒活菌株的新见解
3. Impaired binding of standard initiation factors eIF3b, eIF4G and eIF4B to domain V of the live-attenuated coxsackievirus B3 Sabin3-like IRES - alternatives for 5′UTR-related cardiovirulence mechanisms [J] . Amira Souii, Jawhar Gharbi, Manel Ben M’hadheb-Gharbi Diagnostic pathology . 2013,第S1期

机译：标准起始因子eIF3b，eIF4G和eIF4B与减毒活的柯萨奇病毒B3 Sabin3样IRES的结构域V的结合受损-5'UTR相关心脏毒性机制的替代物
4. Computational analysis of the synonymous codon usage bias in human coxsackievirus B3 strain 28 [C] . Quek Albert, Sim-Hui Tee 2013 IEEE Business Engineering and Industrial Applications Colloquium . 2013

机译：人柯萨奇病毒B3株28同义密码子使用偏倚的计算分析
5. Influenza virus noninfectious biologically active particle subpopulations: Detection, quantification, genetic complexity, function and their novel use as an in vitro screen for self-adjuvating live-attenuated influenza vaccines. [D] . Ngunjiri, John Muthumbi. 2012

机译：流感病毒非感染性生物活性颗粒亚群：检测，定量，遗传复杂性，功能及其作为自筛选减毒活流感疫苗的体外筛选的新用途。
6. Ribosomal Initiation Complex Assembly within the Wild-Strain of Coxsackievirus B3 and Live-Attenuated Sabin3-like IRESes during the Initiation of Translation [O] . Amira Souii, Manel Ben M’hadheb-Gharbi, Bruno Sargueil, 2013

机译：柯萨奇病毒B3和活体减毒的Sabin3样IRES的野生株内核糖体启动复杂大会翻译期间。
7. Molecular Analysis of RNA-RNA Interactions between 5’ and 3’ Untranslated Regions during the Initiation of Translation of a Cardiovirulent and a Live-Attenuated Coxsackievirus B3 Strains [O] . Manel Ben M', Amira Souii, Jawhar Gharbi 2013

机译：启动心毒性和活弱柯萨奇病毒B3株翻译过程中5'和3'非翻译区之间RNA-RNA相互作用的分子分析。

Characterization of attenuated coxsackievirus B3 strains and prospects of their application as live-attenuated vaccines.

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