In vitro Metabolic Modulation of Aryl Sulfotransferases by Pharmaceutical Excipients

摘要

Pharmaceutical excipients (PEs) are an essential part of drug products to make them have desirable characteristics. Most pharmaceutical excipients have been considered as biologically inert. However, recent studies showed that PEs affect pharmacokinetic behaviors of drugs in several manners when absorbed through gastrointestinal (GI) tract. For example, oral administration of the excipients such as non-ionic surfactants could modulate cytochrome P450 enzymes, in GI tract and liver, and p-glycoprotein (p-gp) leading to changes in pharmacokinetic characteristics in vitro and in vivo.