Highly Diastereoselective Indium-Mediated Allylation of Proline-Derived Hydrazones

摘要

Diastereoselective allylation of imines bearing a chiral auxiliary is a reliable, efficient, and powerful strategy for the construction of optically pure homoallylic amines, which are important precursors and key intermediates in syntheses of natural products.Many chiral imines, such as chiral N-aliphatic imines, hydrazones, and N-sulfinyl imines, have been used for diastereoselective allylations. Of these surrogates, chiral hydrazones have proven to be candidates of choice as they offer many advantages including high reactivity and high regioselectivity.