A Novel Synthesis of Heterocyclic Analogues of Thioflavanones from Haloheteroaromatic Carboxylic Acids

摘要

Thioflavanones (2-phenylthiochroman-4-ones), the thio analogues of flavanones, are an interesting class of hetero-cycles because their biological activities sometimes can be improved. We recently investigated the anticancer effects of thioflavanone in MCF-7 human breast cancer cell lines and found that it inhibited cellular proliferation by inducing apoptosis with weak cytotoxicity. The 3-cinnamylidene derivatives of thioflavanones showed antiproliferative effects on mouse lymphoma cells, and the 3-chloromethylene derivatives of thiochroman-4-ones showed antifungal activities.