Fabricating Fibrinogen Microfibers with Aligned Nanostructure, as Biodegradable Threads for Tissue Engineering

摘要

Biocompatible and biodegradable polymer fibers from several microns to few submicron sizes are appealing for various biomedical applications, such as tissue engineering, wound dressings, and drug delivery of sensitive biomole-cules. Especially, the natural biopolymers received much attentions for the past two decades due to their non-immunogenicity, biodegradability, and biocompatibility, where they could easily bind with variety of cells through specific biochemical interactions. Furthermore, the polymer carriers with aligned nanostructures with pores could be more useful for sustained release of active biomolecules, as well as, providing orientations for specific cell growth. In addition, porous surface in fiber could also maintain controlled bioavailability and drug delivery capability, facilitating cell growth, proliferation, accommodation, and transportation of nutrients and waste metabolites.