首页> 外文期刊>Evidence-based complementary and alternative medicine: eCAM >beta-Caryophyllene, a Compound Isolated from the Biblical Balm of Gilead (Commiphora gileadensis), Is a Selective Apoptosis Inducer for Tumor Cell Lines
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beta-Caryophyllene, a Compound Isolated from the Biblical Balm of Gilead (Commiphora gileadensis), Is a Selective Apoptosis Inducer for Tumor Cell Lines

机译:β-石竹烯是从吉利德(Commiphora gileadensis)的圣经香脂中分离出来的化合物,是肿瘤细胞系的选择性凋亡诱导剂。

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摘要

The biblical balm of Gilead (Commiphora gileadensis) was investigated, in this study for anticancerous activity against tumor cell lines. The results obtained from ethanol-based extracts and from essential oils indicated that beta-caryophyllene (trans-(lR,9S)-8-methylene-4,11,11-trimethylbicyclo[ 7.2.0] undec-4-ene) is a key component in essential oils extracted from the balm of Gilead. beta-Caryophyllene can be found in spice blends, citrus flavors, soaps, detergents, creams, and lotions, as well as in a variety of food and beverage products, and it is known for its anti-inflammatory, local anaesthetic, and antifungal properties. It is also a potent cyto-toxic compound over a wide range of cell lines. In the current paper, we found that Commiphora gileadensis stem extracts and essential oil have an antiproliferative proapoptotic effect against tumor cells and not against normal cells, beta-caryophyllene caused a potent induction of apoptosis accompanied by DNA ladder and caspase-3 catalytic activity in tumor cell lines. In summary, we showed that C. gileadensis stems contain an apoptosis inducer that acts, in a selective manner, against tumor cell lines and not against normal cells.
机译:研究了吉利德(Commiphora gileadensis)的圣经香脂对肿瘤细胞系的抗癌活性。从基于乙醇的提取物和精油中获得的结果表明,β-叶绿素烯(反式-(lR,9S)-8-亚甲基-4,11,11-三甲基双环[7.2.0]十一烷基-4-烯)是从吉利德的香脂中提取的精油中的关键成分。 β-石竹烯存在于香料混合物,柑橘香精,肥皂,洗涤剂,乳霜和乳液中,以及多种食品和饮料产品中,并以其抗炎,局部麻醉和抗真菌特性而闻名。 。它也是广泛的细胞系中有效的细胞毒性化合物。在当前的论文中,我们发现Commidephora gileadensis茎提取物和精油对肿瘤细胞具有抗增殖的促凋亡作用,而对正常细胞没有抗增殖作用,β-石竹烯能有效诱导细胞凋亡,并伴随着DNA阶梯和caspase-3催化活性细胞系。总而言之,我们显示了吉列德梭菌茎包含凋亡诱导剂,其以选择性的方式作用于肿瘤细胞系而不是正常细胞。

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