Antipsychotics for aggressive behaviour: no better than placebo for non-psychotic adults with learning difficulties.

摘要

Question: Do risperidone or haloperidol reduce aggressive challenging behaviour more than placebo in people with intellectual disability?Patients: 86 adults with intellectual disability (intelligence quotient <75 and aggressive challenging behaviour (3=2 episodes of aggressive behaviour, modified overt aggression scale (MOAS) score 3=4 in past 7 days), but who had not received a clinical diagnosis of psychosis. Exclusions: depot or injected antipsychotics in the past 3 months, oral antipsychotics in the past week; currently sectioned under the Mental Health Act.