Antidepressant use during first trimester not associated with risk of major congenital malformations.

摘要

Question: Does duration of antidepressant use during the first trimester of pregnancy increase the risk of major congenital malformations?People: 2329 women, pregnant between 1 January 1998 and 31 December 2002, meeting the following inclusion criteria: one diagnosis of psychiatric disorder before pregnancy (ICD-9); antidepressant use for 30 days or more in the year prior to pregnancy; aged 15-45 years at the beginning of pregnancy; and live or still birth at the end of pregnancy. Women were identified using three administrative databases of the Province of Quebec (RAMQ, MED-ECHO and ISQ databases). Mailed questionnaires were used to elicit information on confounding variables such as income, education, ethnicity and lifestyle factors. Exclusion criteria: women with mental retardation, certain psychotic or non-psychotic conditions; abortion and miscarriage. Setting: Province of Quebec, Canada; recruitment January 1998-December 2002.