Review: dietary plus pharmacological intervention (orlistat or sibutramine) induces long term weight loss in overweight or obese adults

摘要

Dietary/lifestyle therapy 16 studies (n = 5698) met the selection criteria Mean patient age tanged from 40 to 59 years, and mean weight at baseline ranged from 78 to 116 kg. Dietary/lifestyle interventions comprised very low calorie diets (<1100 kcal/d) or low calorie diets (1200-1500 kcal/d), sometimes combined with behaviour counselling/lifestyle modification. In 13 trials, weight loss was assessed during a 3-18 month induction phase followed up by a 12-36 month weight loss maintenance phase after the intervention In 3 trials, weight loss was assessed only during the 24-48 month induction period Meta-analysis was not done because of study heterogeneity. Weight loss was usually <5 kg after 2-3 years and 1 8-10,0 kg after 4-7 years.