Review: central venous catheters treated with anti-infective agents prevent catheter-related bloodstream infections.

摘要

QUESTION Do central venous catheters treated with anti-infective agents (AI-CVCs) prevent catheter-related bloodstream infections (CRBSIs)? REVIEW SCOPE Included studies compared AI-CVCs with standard CVCs or a different AI-CVC for preventing CRBSIs in patients requiring a CVC. Primary outcome was diagnosis of a CRBSI (the same micro-organism identified in both the catheter and the bloodstream). iEVlEW METHODS Medline, EMBASE/Excerpta Medica, SCI/Web of Science, SCI/ISI Proceedings, and Cechram Library (to Sep 2007) were searched for randomised controlled trials (RCTs). Trials involving AI-CVCs that required in-house preparation were excluded. 38 RCTs (n = ~9000 patients) met the selection criteria. Methodological quality of the trials was generally poor: 10 RCTs reported adequate concealment of allocation, and 19 RCTs reported blinding of patients, healthcare providers, or outcome assessors. 27 trials that reported appropriate measures of CRBSI were included in the meta-analysis. 6 trials compared 2 different AI-CVCs, but results were not reported in this paper.*