Oral vitamin D_3 supplementation reduced fractures in community dwelling elderly people

摘要

Randomised (unclear allocation concealment), blinded (participants and clinicians), placebo controlled trial with 5 years of follow up.Community based study with participants recruited from the British Doctors Study register and a general practice register in Suffolk, UK.2686 elderly people 65-85 years of age (mean age 75 y, 76% men) who were living in the general community. Exclusion criteria included current use of vitamin D_3 supplements and contraindications to vitamin D_3 supplementation such as a history of renal stones, sarcoidosis, or malignancy.