Switching to aripiprazole from olanzapine leads to weight loss in overweight people with schizophrenia or schizoaffective disorder.

摘要

Question: Does switching to aripiprazole from olanzapine improve metabolic status in overweight people with schizophrenia or schizoaffective disorder? Patients: Patients with schizophrenia or schizoaffective disorder (DSM-IV-TR) treated with olanzapine only (10-20 mg/day for 1-24 months). Inclusion criteria: body mass index s=27; Clinical Global Impressions-Severity score <4. Main exclusion criteria: other axis I disorder; diabetes; neurological condition or mental retardation; suicide risk; alcohol or drug dependence or electroconvulsive therapy 3 months prior to study; previous failure to respond to aripiprazole; clinically significant ECG, blood result or vital sign; pregnant, breastfeeding or not reliably using contraception for the duration of the study plus 4 weeks after study completion.