Antiepileptic drug use during pregnancy: Sodium valproate is associated with lower offspring IQ

摘要

Context: The individual impact of each drug on cognitive outcomes, such as the developmental and IQs varies, with reports showing that IQ is affected in children exposed to sodium valproate compared to phenytoin, carba-mazepine and lamotrigine. Some research has demonstrated that children exposed to sodium valproate during pregnancy had increased likelihood of difficulty with adaptive functioning and of attention deficit hyperactivity disorder (ADHD). The current data on the relative safety of newer AEDs in pregnancy are limited due to the relatively short time of commercial availability of the agents and the need for longer clinical and functional follow-up for children exposed to AEDs.