Second generation antipsychotics are not superior in relieving family burden in schizophrenia compared with the first generation antipsychotic perphenazine.

摘要

Question: Are second generation antipsychotics superior to first generation antipsychotics for reducing family burden associated with schizophrenia?Patients: 623 family caregivers of patients with schizophrenia (SCID diagnosed) enrolled in the CATIE trial. Main exclusions for patients: schizoaffective disorder, first episode schizophrenia, treatment resistant schizophrenia, mental retardation or other cognitive disorder. Setting: 57 US sites; January 2001 to December 2004.