The protective effect of Compound Yangshen Granules was observed in myocardial infarction rat model. Rats were randomly divided into 6 groups: the model group, the control group (sham operated), the positive drug group, and small, medium, and large dosage of the Yangshen granule groups, respectively. The rats in the 3 Yangshen granule groups were orally administrated with 0.7 g/kg, 1.4 g/kg, and 2.8 g/kg for 7 consecutive days, whereas the rats of the positive drug group treated with 0.14 g/kg of Danshen Dropping Pills, and rats in the control and model groups orally administrated with saline. The rat model of acute myocardial infarction was established with ligation of coronary artery. Electrocardiograms at different time points, the blood rheology, myocardial enzymes, infarct size, and myocardial morphologic changes were measured. The results demonstrated that the granules could improve blood rheology, decrease st-segment of electrocardiograms and the activities of LDH and CK in serum, reduce myocardial infarction size, and alleviate myocardial histopathologic changes. In addition, the effect of the granules depended on the dose administrated orally. The results suggest that the Yangshen granules could produce cardioprotection effect and have potential benefits in the prevention of ischemic heart disease.
展开▼
机译：观察复方养肾颗粒对心肌梗死大鼠的保护作用。将大鼠随机分为6组：模型组，对照组（假手术组），阳性药物组和小，中，大剂量的养肾颗粒组。连续3天口服3个养肾颗粒组的大鼠0.7 g / kg，1.4 g / kg和2.8 g / kg，而阳性药物组的大鼠口服0.14 g / kg的丹参滴丸，对照组和模型组的大鼠口服生理盐水。结扎冠状动脉建立大鼠急性心肌梗死模型。测量不同时间点的心电图，血液流变学，心肌酶，梗塞面积和心肌形态变化。结果表明，该颗粒可改善血液流变学，降低心电图的节段性，降低血清中LDH和CK的活性，减少心肌梗塞的大小并减轻心肌的组织病理学变化。另外，颗粒的作用取决于口服剂量。结果表明，养肾冲剂具有保护心脏的作用，对缺血性心脏病的预防具有潜在的益处。
展开▼
