Adenylate Deaminase (5'-Adenylic Acid Deaminase, AMPDA)-Catalyzed Deamination of 5'-Deoxy-5'-Protected Adenosines: A Comparison with the Catalytic Activity of Adenosine Deaminase (ADA)

摘要

The enzyme adenylate deaminase (AMPDA) is able to catalyze the hydrolytic deamination of 5'-substituted and 5'-protected 5'-deoxyadenosines, whereas limited or no activity is shown by adenosine deaminase (ADA) towards the same substrates.