Influence of monosubstitution of hexakis(3,6-anhydro)cyclomaltohexaose on its complexation properties with ions, with special attention to heavy metals

摘要

We report on the synthesis, characterisation and ionic complexation properties of mono-2-O-carboxymethyl-hexa-kis(3,6-anhydro)cyclomaltohexaose sodium salt 1, as investigated by TLC and NMR. We demonstrate that the grafting of a carboxylate group not only modifies the complexation. proper-ties of the parent derivative in relation to heavy metals but also improves them. In this respect, we provide evidence that the gain in affinity is due to the cumulative effects of the molecular cage and the carboxylate group. Coupling of I to insoluble supports (bio-polymers, liposomes,...) might be expected to afford new materials for the elimination of toxic metals in biological fluids or organs. ((c) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006).