An efficient one-pot synthesis of dihydropyrimidinones by a samarium diiodide catalyzed Biginelli reaction under solvent-free conditions

摘要

The Biginelli reaction, a one-pot condensation of aldehydes, urea or thiourea, and beta-dicarbonyl compounds, is efficiently catalyzed by samarium diiodide. The biologically active dihydropyrimidinones are easily synthesized in moderate to excellent yields under solvent-free conditions. ((c) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005).