The development of domino reactions incorporating the heck reaction: The formation of N-heterocycles

摘要

The methodological development of a series of domino or cascade reactions affording a series of N-heterocycles is described. The rapid formation of these ring systems is in each case associated with the incorporation of a Heck reaction at either an early or a late stage of the domino process. A range of catalytic conditions and substrate modifications for optimisation of domino Tsuji-Trost/Heck, Buchwald-Hartwig/Heck and Heck/carbopalladation reaction sequences are reported. The development of a series of domino or cascade reactions affording a collection of N-heterocycles is described. In each of the processes a palladium-catalysed Heck cross-coupling reaction in utilised to produce the desired ring system efficiently.