First Model Reactions towards the Synthesis of Sarain A Core Skeleton Based upon a Biogenetic Scenario

摘要

Sarain A is a complex macrocyclic marine alkaloid extracted from sponges of the order Haplosclerida.It is likely that this alkaloid shares a common origin with manzamine alkaloids,also extracted from sponges of the same order.In this paper,new concepts concerning this origin are presented and constitute the basis for a synthetic strategy.A preliminary evaluation of this strategy is presented and leads,as a first result,to a five-step access to the bicyclic intermediate 43.