Oxidation of 3,4-Diaryl-2,5-dihydrothiophenes to 3,4-Diarylthiophenes Using CuBr2:Simple and Efficient Preparation of 3,4-Diarylthiophenes

摘要

A class of 3,4-diarylthiophenes was prepared in excellent yield(80-91%)by oxidation of 3,4-diaryl-2,5-dihydrothio-phenes with CuBr2.The approach is also available for the synthesis of 3,4-diarylpyrroles and 3,4-diarylfuran.3,4-Disubstituted thiophenes are one of the most important class of heterocyclic compounds,not only as building blocks in the synthesis of natural products or as key structural units of compounds with interesting biological activities but also in the field of materials chemistry.