Nickel-Catalyzed Solvent-Free Three-Component Coupling of Aldehyde, Alkyne and Amine

摘要

A versatile three-component coupling of aldehydes, alkynes and amines has been developed, catalyzed by Ni2+ exchanged Y-zeolite, which acts as all environmentally benign, recyclable, efficient and heterogeneous catalyst This three-component (A(3)) coupling (reported for the first time to proceed under nickel catalysis) is carried out under solvent-free conditions, and the corresponding propargylamines are obtained in good to excellent yields