Comparison of the effect of sodium hyaluronate (Ophthalin) and hydroxypropylmethylcellulose (HPMC-Ophtal).

摘要

PURPOSE. To prospectively evaluate the effects of 2% hydroxypropyl-methylcellulose (HPMC-Ophtal(R)) and sodium hyaluronate 1% (Ophthal in (R)) on intraocular pressure, corneal thickness, and endothelial cell loss in small incision cataract surgery with implant. METHODS. A total of 110 patients undergoing routine phacoemulsification with implant received either 2% hydroxypropyl methylcellulose or sodium hyaluronate 1% as ophthalmic viscosurgical device. Pre- and postoperative slitlamp examination, intraocular pressure measurement (preoperatively and at 1-4 hours, 1 day, and 7 days postoperatively), ultrasonic pachymetry (preoperatively and at 1 week, 4-6 weeks, and 12 weeks post operatively), and corneal endothelial cell count (preoperatively and 12 weeks postoperatively) were performed. Data were analyzed using two-way analysis of variance. RESULTS. All measurements were comparable between the two groups preoperatively. Intraocular pressure was significantly lower in the Ophthalin(R) group at 1 day post operatively, while no significant difference was found between the two groups on the 1-4 hours and 7 days examination. The central corneal thickness was not significantly different between the two groups at any postoperative visit . However, the mean cell density demonstrated a significant fall of 11.76% for Ophthalin(R) and 4.27% for HPMC-Ophtal(R) at 12 weeks post-operatively, the difference between the two being significant (p=0.009). CONCLUSIONS. 2% Hydroxypropyl methylcellulose, compared with sodium hyaluronate 1%, is superior in protecting the corneal endothelial cells, has the same effect on central corneal thickness, and is associated with slightly higher intraocular pressure 1 day post operatively. It compares favorably with sodium hyaluronate 1% and can be used as an effective and cheaper alternative in routine small incision cataract surgery with implant.