Nifedipine versus placebo in the treatment of preterm prelabor rupture of membranes: a randomized controlled trial Assessment of perinatal outcome by use of tocolysis in early labor- APOSTEL IV trial

摘要

Objective: Preterm birth is the most common cause of neonatal morbidity and mortality. Around one third of preterm deliveries starts with preterm prelabor rupture of membranes (PPROM). The aim of this trial was to study the effect of prolonged tocolysis with nifedipine versus placebo in women with PPROM on perinatal outcome and prolongation of pregnancy.