We report a child with juvenile polyposis syndrome caused by a defect in the SMAD4 gene who had rapid recurrence of colonic polyps after initiation of growth hormone (GH) for short stature. There was a preponderance of polyps in the right side of the colon, including an appendiceal polyp. The appendiceal polyp was successfully removed endoscopically. We briefly review appendiceal polyps and the role of growth hormone in normal and abnormal colonic growth.
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