Relationship between chemokine (C-X-C motif) ligand 12 gene variant (rs1746048) and coronary heart disease: Case-control study and meta-analysis

摘要

The goal of our study is to evaluate the contribution of CXCL12 rs1746048 (hg19, chr10:44775574) to the risk of CHD in Han Chinese, and to summarize its role in CHD through meta-analysis of existing studies among various ethnic groups. Significant association is observed between rs1746048-C and an increased risk of CHD in Han Chinese (χ2=5.41, df=1, P=0.02). Post hoc analysis reveals an even stronger association of rs1746048 with the risk of CHD for subjects aged 65years or older (genotype: χ2=8.39, df=2, P=0.015; allele: χ2=9.13, df=1, P=0.003, odd ratio (OR)=1.91, 95% confidential interval (CI)=1.25-2.91). A break down analysis by gender shows that rs1746048 is likely a CHD risk factor under the recessive model in males (CC+CT versus TT: P=0.05, χ2=3.59, df=1, OR=1.72, 95% CI=1.00-3.04). In addition, a meta-analysis of ten studies among over 107,000 individuals confirms that rs1746048 is a risk factor of CHD (P0.0001, OR=1.12, 95% CI=1.09-1.15) and this agrees with the findings of our case-control study in Han Chinese.