PRKCE gene encoding protein kinase C-epsilon-Dual roles at sarcomeres and mitochondria in cardiomyocytes

摘要

Protein kinase C-epsilon (PKCc) is an isoform of a large PKC family of enzymes that has a variety of functions in different cell types. Here we discuss two major roles of PKCe in cardiac muscle cells; specifically, its role in regulating cardiac muscle contraction via targeting the sarcomeric proteins, as well as modulating cardiac cell energy production and metabolism by targeting cardiac mitochondria. The importance of PKCE action is described within the context of intracellular localization, as substrate selectivity and specificity is achieved through spatiotemporal targeting of PKCc. Accordingly, the role of PKCe in regulating myocardial function in physiological and pathological states has been documented in both cardioprotection and cardiac hypertrophy. (C) 2016 Elsevier B.V. All rights reserved.