Receptor tyrosine kinase-like orphan receptor 1: a novel target for cancer immunotherapy

摘要

Introduction: Receptor tyrosine kinase-like orphan receptor 1 (ROR1) is a member of the receptor tyrosine kinase family. ROR1 is selectively overexpressed in a number of solid and hematological malignancies without significant expression in normal adult tissues. There are also some lines of evidence, which support the critical role of ROR1 in tumorigenesis. These characteristics introduce ROR1 as a suitable target for selective cancer immunotherapy. ROR1 targeting using different approaches such as siRNA, tyrosine kinase inhibitors and antibody induces tumor growth suppression in cancer cells.