Pharmacological basis and scientific rationale underlying the targeted use of inhaled corticosteroid/long-acting beta(2)-adrenergic agonist combinations in chronic obstructive pulmonary disease treatment

摘要

Introduction: Chronic obstructive pulmonary disease (COPD) is a complex respiratory disorder, whose medical and socioeconomic burden as one of the main causes of morbidity and mortality is increasing worldwide. COPD pathophysiology includes chronic airway/lung inflammation and progressive airflow limitation. Therefore, anti-inflammatory and bronchodilator agents are key players in COPD treatment.