Potential of growth hormone-releasing hormone antagonists (JV-1-36 and JV-1-42) for the treatment of brain tumours

摘要

Malignant glioblastoma is the most common type of primary brain tumour in adults.Current therapies are palliative and prolong quality survival.JV-1-36 and JV-1-42 are examples of peptide growth hormone-releasing hormone antagonists.JV-1-36 has been shown to decrease the size of subcutaneous human glioblastoma tumours in nude mice,and to extend the survival of nude mice implanted orthotopically with glioblastoma.JV-1-42 has been shown to cross the blood-brain barrier very effectively in mice;thus,the JV series of growth hormone-releasing hormone antagonists are showing promise for glioblastoma and should be further developed for the treatment of this condition.