Dissecting DBS Dynamics through quantitative behavioral assessments and statistical modeling: A commentary on Cooper et al. 2011

摘要

Deep brain stimulation (DBS) is a rapidly evolving method for treatment of neurological and psychiatric disorders (Lyons, 2011). While accumulated evidence strongly supports the initial origins of all DBS effects in the driving of action potentials by changing the transmem-brane electrical potential of neurons and their axonal elements nearby the electrodes (Ranck, 1975; Chan and Nicholson, 1986; Chan et al, 1988; Garcia et al., 2003; Tranchina and Nicholson, 1986; Miocinovic et al., 2009; Butson et al., 2011), uncovering the mechanisms producing clinically relevant effects in specific applications of DBS techniques remains a considerable challenge (Ponce and Lozano, 2011; McIntyre and Hahn, 2010).