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首页> 外文期刊>Experimental Hematology: Official Publication of the International Society for Experimental Hematology >COMPUTER-AIDED SCREENING IDENTIFIED A NOVEL SMALL INHIBITOR THAT DISPLAYS POTENT ANTI-MYELOMA ACTIVITY BY SUPPRESSING CONSTITUTIVE AND INTERLEUKIN-6-TRIGGERED JAK2-STAT3 ACTIVATION

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COMPUTER-AIDED SCREENING IDENTIFIED A NOVEL SMALL INHIBITOR THAT DISPLAYS POTENT ANTI-MYELOMA ACTIVITY BY SUPPRESSING CONSTITUTIVE AND INTERLEUKIN-6-TRIGGERED JAK2-STAT3 ACTIVATION

机译：计算机辅助筛选通过抑制本构和白介素6触发的JAK2-STAT3激活，显示了一种新型的小抑制剂，该抑制剂可显示潜在的抗骨髓瘤活性

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《Experimental Hematology: Official Publication of the International Society for Experimental Hematology》 |2013年第1期|共1页
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正文语种 eng
中图分类血液及淋巴系疾病;
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1. COMPUTER-AIDED SCREENING IDENTIFIED A NOVEL SMALL INHIBITOR THAT DISPLAYS POTENT ANTI-MYELOMA ACTIVITY BY SUPPRESSING CONSTITUTIVE AND INTERLEUKIN-6-TRIGGERED JAK2-STAT3 ACTIVATION [J] . Experimental Hematology: Official Publication of the International Society for Experimental Hematology . 2013,第8Suppla1期

机译：计算机辅助筛选通过抑制本构和白介素6触发的JAK2-STAT3激活，显示了一种新型的小抑制剂，该抑制剂可显示潜在的抗骨髓瘤活性
2. SKLB1206, a Novel Orally Available Multikinase Inhibitor Targeting EGFR Activating and T790M Mutants, ErbB2, ErbB4, and VEGFR2, Displays Potent Antitumor Activity Both In Vitro and In Vivo. [J] . Youli Pan, Yong Xu, Shan Feng, Molecular cancer therapeutics . 2012,第4期

机译：SKLB1206是靶向EGFR激活和T790M突变体ErbB2，ErbB4和VEGFR2的新型口服多激酶抑制剂，在体外和体内均显示出强大的抗肿瘤活性。
3. Potent anti-myeloma activity of the TOPK inhibitor OTS514 in pre-clinical models [J] . Progress in Artificial Intelligence . 2020,第1期

机译：临床前模型中TOPK抑制剂OTS514的有效抗骨髓瘤活性
4. MOLECULAR DOCKING BASED SCREENING OF"NITROGEN CONTAINING BISPHOSPHONATE CONJUGATE WITH HYDROXYAPATITE"ACTIVE CONSTITUENTS TOWARDS MEVALONATE PATHWAY IN FINDING POTENT INHIBITORS FOR ANTI-OSTEOPOROTIC ACTIVITY [C] . Kalyani A., Bharath Srinivasan, Parasuraman P. Conference on Drug Design and Discovery Technologies . 2020

机译：基于分子对接的筛选“含羟基磷灰石与羟基磷酸盐”活性成分对甲氨酸途径的活性成分，寻找抗骨质疏松活性的有效抑制剂
5. P27 as a molecular target for cancer therapeutics: Discovering small molecule inhibitors of p27 proteolysis and structure-activity relationship and mechanistic studies of largazole, a potent inhibitor of histone deacetylase . [D] . Ungermannova, Dana. 2010

机译：P27作为癌症治疗的分子靶标：发现p27蛋白水解和结构活性关系的小分子抑制剂以及组蛋白脱乙酰基酶的有效抑制剂largazole的机理研究。
6. Correction: A novel small molecule agent displays potent anti-myeloma activity by inhibiting the JAK2-STAT3 signaling pathway [O] . Zubin Zhang, Hongwu Mao, Xiaolin Du, 2016

机译：校正：一种新型的小分子药物通过抑制JAK2-STAT3信号通路显示出有效的抗骨髓瘤活性
7. SKLB1206, a Novel Orally Available Multikinase Inhibitor Targeting EGFR Activating and T790M Mutants, ErbB2, ErbB4, and VEGFR2, Displays Potent Antitumor Activity Both In Vitro and In Vivo [O] . Youli Pan, Yong Xu, Shan Feng, 2012

机译：SKLB1206，一种靶向EGFR活化和T790M突变体，ERBB2，ERBB4和VEGFR2的新型口服多立糖酶抑制剂，在体外和体内显示有效的抗肿瘤活性

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