Physiopathological factors affecting the diagnostic value of serum HE4-test for gynecologic malignancies

摘要

Introduction: Serum epididymis protein 4 (HE4) represents a useful biomarker for the management of ovarian cancer and endometrial cancer patients. However, HE4 levels are affected by many physiopathological conditions or disorders that should be taken into consideration for an efficient application of this biomarker.