INCIDENCE, RECURRENCE, AND OUTCOMES OF HERPES SIMPLEX VIRUS EYE DISEASE IN OLMSTED COUNTY, MINNESOTA, 1976-2007: THE EFFECT OF ORAL ANTIVIRAL PROPHYLAXIS

摘要

Original study reprint requests: Keith H. Baratz, MD, Department of Ophthalmology, Mayo Clinic, 200 First St. SW, Rochester, MN 55905. E-mail address: baratz.keith@mayo.edu. Research Objective To estimate the incidence of herpes simplex virus (HSV) eye disease in a community-based cohort and to study the long-term use of prophylactic oral antiviral therapy to determine if it affected the frequency of recurrences and adverse outcomes due to ocular HSV. Study Design Retrospective, observational cohort study. Location Olmsted County, Minnesota. Funding Source Research to Prevent Blindness and the Mayo Foundation. Relevant Methodology Using the Rochester Epidemiology Project (REP) medical records linkage system, all potential incident cases of HSV eye disease were captured from January 1, 1976 to December 31, 2007. All charts were retrospectively reviewed.