Pathomorphology of hepatocytes of rats treated with adriamycin.

摘要

The aim of this study was ultrastructural and light microscopical assessment of the adriamycin-induced apoptosis in rats' hepatocytes. The studied material consisted of Wistar rats divided into four equal groups: two experimental - rats treated with a single intraperitoneal dose of adriamycin (5 mg/kg b.w.) and decapitated after 4 and 7 weeks; and two control - rats treated with a single intraperitoneal dose of 0.9% NaCl (0.5 ml) and decapitated after 4 and 7 weeks. Specimens of the liver were observed under light and electron microscopes (semi thin slides). Typical apoptotic lesions were observed. The applied dose of adriamycin seems to be suitable to induce the cell death through apoptosis and too small to cause necrosis.