OPEN CLINICAL STUDY OF EYE-DROPS CONTAINING TETRAPEPTIDES DERIVED FROM SUBSTANCE P AND INSULIN-LIKE GROWTH FACTOR-1 FOR TREATMENT OF PERSISTENT EPITHELIAL DEFECTS ASSOCIATED WITH NEUROTROPHIC KERATOPATHY

摘要

Research Objective To examine the clinical efficacy of a combination eye drop of a substance P-derived peptide (FGLM-amide) and an insulin-like growth factor-1 (IGF-l)-derived peptide (SSSR) for the treatment of persistent cor-neal epithelial defects in individuals with neurotrophic keratopathy. Study Design Prospective open label study. Location Yamaguchi University Graduate School of Medicine, Ube City, Japan. Funding Source None listed. Relevant Methodology Twenty-six eyes of 25 patients with persistent epithelial defects associated with neurotrophic keratopathy were treated with eye drops containing a substance P-derived peptide (FGLM-amide) and insulin-like growth factor-1 (SSSR). Epithelial healing was monitored by slit-lamp examination.