Efficacy and Safety of Methotrexate in Combination with Other Non-biologic Disease-modifying Antirheumatic Drugs (DMARDs) in Treatment of Rheumatoid Arthritis

摘要

A PubMed search was performed to search for studies that included at least one arm of treatment involving MTX in combination with other non-biologic DMARDs. We used the following search terms: rheumatoid arthritis, randomized trial, MTX, DMARDs, triple therapy rheumatoid, and combination therapy to retrieve clinical trials, including combination therapy of MTX with other DMARDs. We also performed a hand search of references from the included reports. The search yielded 21 clinical trials, but the review was not exhaustive. It was not possible to pool these trials because of different interventions and primary outcomes. Therefore, a brief summary of each trial is presented, including description of participants, duration of the study, intervention, primary outcome, and results.