Effects of Cabozantinib on Pain and Narcotic Use in Patients with Castration-resistant Prostate Cancer: Results from a Phase 2 Nonrandomized Expansion Cohort

Basch Ethan; Autio Karen A.; Smith Matthew R.; Bennett Antonia V.; Weitzman Aaron L.; Scheffold Christian; Sweeney Christopher; Rathkopf Dana E.; Smith David C.; George Daniel J.; Higano Celestia S.; Harzstark Andrea L.; Sartor A. Oliver; Gordon Michael S.; Vogelzang Nicholas J.; de Bono Johann S.; Haas Naomi B.; Corn Paul G.; Schimmoller Frauke; Scher Howard I.

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Effects of Cabozantinib on Pain and Narcotic Use in Patients with Castration-resistant Prostate Cancer: Results from a Phase 2 Nonrandomized Expansion Cohort

机译：卡博替尼对去势抵抗性前列腺癌患者疼痛和麻醉剂使用的影响：2期非随机扩展队列的结果

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Background: Pain negatively affects quality of life for cancer patients. Preliminary data in metastatic castration-resistant prostate cancer (mCRPC) suggested a benefit of the oral tyrosine kinase inhibitor cabozantinib to pain palliation.

机译：背景：疼痛会对癌症患者的生活质量产生负面影响。转移性去势抵抗性前列腺癌（mCRPC）的初步数据表明，口服酪氨酸激酶抑制剂卡博替尼对缓解疼痛有好处。

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《European urology》 |2015年第2期|共9页
作者
Basch Ethan; Autio Karen A.; Smith Matthew R.; Bennett Antonia V.; Weitzman Aaron L.; Scheffold Christian; Sweeney Christopher; Rathkopf Dana E.; Smith David C.; George Daniel J.; Higano Celestia S.; Harzstark Andrea L.; Sartor A. Oliver; Gordon Michael S.; Vogelzang Nicholas J.; de Bono Johann S.; Haas Naomi B.; Corn Paul G.; Schimmoller Frauke; Scher Howard I.;
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正文语种 eng
中图分类泌尿科学（泌尿生殖系疾病）;
关键词
mCRPC; Pain control; Patient-reported outcomes; Phase 2 trial; Quality of life; Tyrosine kinase inhibitor;

机译：mCRPC;疼痛控制;患者报告的结果;第二阶段试验;生活质量;酪氨酸激酶抑制剂;

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1. Effects of Cabozantinib on Pain and Narcotic Use in Patients with Castration-resistant Prostate Cancer: Results from a Phase 2 Nonrandomized Expansion Cohort [J] . Basch Ethan, Autio Karen A., Smith Matthew R., European urology . 2015,第2期

机译：卡博替尼对去势抵抗性前列腺癌患者疼痛和麻醉剂使用的影响：2期非随机扩展队列的结果
2. Cabozantinib in chemotherapy-pretreated metastatic castration-resistant prostate cancer: Results of a phase II nonrandomized expansion study [J] . SmithM.R., SweeneyC.J., CornP.G., Journal of Clinical Oncology . 2014,第30期

机译：Cabozantinib在化疗 - 预处理转移性阉割前列腺癌：II期非粗糙扩张研究的结果
3. Changes in plasma biomarkers following treatment with cabozantinib in metastatic castration-resistant prostate cancer: a post hoc analysis of an extension cohort of a phase II trial [J] . Raya Leibowitz-Amit, Melania Pintilie, Leila Khoja, Journal of Translational Medicine . 2016,第1期

机译：卡博替尼治疗转移性去势抵抗性前列腺癌后血浆生物标志物的变化：II期试验扩展研究组的事后分析
4. Metastatic Hormone-Sensitive and Castration-Resistant Prostate Cancer: A Decade of Progress and Ongoing Discoveries [C] . Leonel Hernez-Aya, Maha Hussain Genitourinary Cancers Symposium. . 2014

机译：转移激素敏感和阉割的前列腺癌：进步和持续发现的十年
5. Risk for Cardiovascular Diseases in Prostate Cancer Patients Treated with Androgen Deprivation: A Population-based Cohort Study [D] . Jiang, Lei. 2018

机译：治疗雄激素剥夺治疗前列腺癌患者心血管疾病的风险：基于人群的群组研究
6. Cabozantinib in Chemotherapy-Pretreated Metastatic Castration-Resistant Prostate Cancer: Results of a Phase II Nonrandomized Expansion Study [O] . Matthew R. Smith, Christopher J. Sweeney, Paul G. Corn, -1

机译：卡波替尼在化疗前治疗的转移性去势抵抗性前列腺癌中的作用：II期非随机扩展研究的结果
7. Cabozantinib in chemotherapy-pretreated metastatic castration-resistant prostate cancer: results of a phase II nonrandomized expansion study [O] . Smith, M., Sweeney, C., Corn, P., 2014

机译：Cabozantinib在化疗预处理的转移性去势抵抗性前列腺癌中的应用：II期非随机扩增研究的结果

Effects of Cabozantinib on Pain and Narcotic Use in Patients with Castration-resistant Prostate Cancer: Results from a Phase 2 Nonrandomized Expansion Cohort

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