Re: A prospective, blinded comparison of magnetic resonance (MR) imaging-ultrasound fusion and visual estimation in the performance of MR-targeted prostate biopsy: The PROFUS trial

摘要

In this single-center prospective, blinded study, the authors compare magnetic resonance imaging (MRI)-ultrasound fusion targeted biopsy (MRF-TB), MRI-visual estimated targeted biopsy (VE-TB, also known as cognitive MRI-targeted biopsy), and standard 12-core biopsy in the detection of prostate cancer (PCa). Patients with suspicious lesions on 3-T MRI were included. Per patient, overall PCa detection was similar between MRF-TB and cognitive biopsy (36% vs 32%; p = 0.36). In addition, Gleason sum >7 PCa detection was similar between MRF-TB and cognitive biopsy (23% vs 19%; p = 0.27). Combined MRI targeted biopsy results were compared with standard biopsy. Standard biopsy detected PCa more often than targeted biopsy (55% vs 40%; p < 0.01). However, detection of Gleason sum >7 PCa was equivalent between standard and targeted biopsy (33% vs 33%; p = 0.68). On multivariate analysis, diameter of MRI suspicious region (mSR) was a predictor of positive MRF-TB and negative VE-TB (odds ratio: 0.83; p<0.01).