Adjuvant radiation following radical prostatectomy: What are the known unknowns?

摘要

For patients with localized prostate cancer (PCa), radical prostatectomy (RP) and external-beam radiotherapy (RT) enable an adjusted 10-yr overall survival (OS) of 83% and 89%, respectively [1 ]. After prostatectomy, 15-25% of the patients experience recurrence [2]. With adverse risk factors such as high serum levels of prostate-specific antigen (PSA), pT3, positive surgical margins (Rl), and Gleason score >8, the 10-yr biochemical recurrence rates may grow to 75% [3]. Although not all PSA-relapsing patients will develop clinical progression, surgery alone may be inadequate for specific subgroups [4].