Re: Use of laptop computers connected to internet through Wi-Fi decreases human sperm motility and increases sperm DNA fragmentation

摘要

To determine the effectiveness of surgery versus observation for men with localized prostate cancer (PCa) in the early prostate-specific antigen (PSA) era, 773 men who were medically fit for radical prostatectomy (RP) were randomly assigned to undergo RP or observation with the offer of palliative or chemotherapy for symptomatic or metastatic progression. Half of the patients had Gleason scores >7, and two-thirds had tumors in the intermediate- or high-risk category. Analyses were based on the intention-to-treat principle. There were no significant differences in median survival (13.0 yr for RP vs 12.4 yr for observation) or death attributed to PCa or its treatment (5.8% vs. 8.4%, respectively). Bone metastases were significantly less in the prostatectomy group (4.7% vs. 10.6%). Subgroup analyses suggested that RP might reduce mortality among men with PSA values >10 and men with intermediate- and high-risk tumors.