A study of RUNX3, E-cadherin and beta-catenin in CagA-positive Helicobacter pylori associated chronic gastritis in Saudi patients

摘要

OBJECTIVE: H. pylori is the most important risk factor for gastric carcinoma. CagA-positive H. pylori is associated with an increased risk for gastric cancer compared with negative strains. RUNX3 is a tumor suppressor gene, which is related to the genesis of gastric cancer. beta-catenin is integrated with E-cadherin in the cell membrane, and aberrant expression of the complex was reported in gastric carcinoma. Aim of this paper is to determine of the relation between RUNX3, E-cadherin and beta-catenin in chronic gastritis associated with cagA-positive H. pylori infection.