Response to the letter to the editor entitled 'Lipid emulsion in acute poisonings: Still no convincing demonstration for its use in non-local anesthetic drug poisoning without life-Threatening presentation'

摘要

We appreciate the comments of Drs. Megarbane and Jacobs on our investigation1. We agree with their suggestion that our study demonstrates the absence of lipid emulsion (LE) benefit in multi-drug poisonings with no other impairments than coma. However, we should add two major points to their comments. First, in the field of general toxicology, the reported rate of adverse effects for LE is very low. To the best of our knowledge, adverse effects from LE in this field is isolated to one instance of acute lung injury- the etiology of which was likely to be multifactorial- and one case of hyperamylasaemia2. Also, in contrast to our study, it has been shown that when high doses of LE are infused in a short space of time, transient hyperlipidemia for three or more hours result in he-moconcentration, false elevation of methemoglobin concentration, hyponatremia, and changes in arterial blood gases,